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500mg tablets of Depakote prolonged-release Valproate or valproic acid is utilised largely to treat epilepsy and bipolar disorder and to prevent migraine headaches.[21]
Plasma clearance and volume of distribution without cost diazepam were reduced by twenty five% and 20%, respectively, within the existence of valproate. The elimination 50 percent-life of diazepam remained unchanged on addition of valproate.
Depakote may cause serious Unintended effects like: See “What exactly is the most important info I really should know about Depakote?”
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Normally people commence in a low dose of medication and the dose is enhanced slowly in excess of several weeks.
1.2 Epilepsy Depakote is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that take place either in isolation or in Affiliation with other kinds of seizures. Depakote is check here usually indicated for use as sole and adjunctive therapy inside the treatment of easy and sophisticated absence seizures, and adjunctively in individuals with a number of seizure types which include absence seizures.
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These highlights never include all the knowledge necessary to use Depakote securely and properly. See total prescribing information and facts for Depakote.
one Headache was the sole adverse reaction that occurred in ≥ 5% of patients in the superior dose team and at an equal or bigger incidence inside the reduced dose group.
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Don't consume alcohol though using Depakote. Depakote and Alcoholic beverages can have an effect on one another creating Unwanted side effects such as sleepiness and dizziness.
drowsiness or sleepiness during the aged. This Severe drowsiness could result in you to try to eat or consume fewer than you Ordinarily would. Notify your healthcare company if you are not capable of eat or consume as you normally do. Your Health care supplier may perhaps start out you in a reduce dose of Depakote.
In some instances, liver injury could proceed Though the medication is stopped. Your healthcare provider will do blood tests to check your liver before and during procedure with DEPAKOTE.